Shorter narrates from the point of view of the practicing psychiatrist. The thesis is that psychiatry has struggled to differentiate itself from neurology (and brain science), psychoanalysis (and psychotherapy), finally securing for itself the secure path of a respectable scientific enterprise in the second psychopharmacological revolution, featuring Prozac (floxatine) along with a willingness to make use of some version of “the rapport,” talking with patients as human beings with complex lives and emotions.